Quaternarization is an important SN2 nucleophilicsubstitutionreaction; solvent has remarkable effect on it.
季铵化反应是一类重要的SN2亲核取代反应,溶剂对该反应的影响很显著。
2
Aripiprazole in overall yield of 68% was synthesized from 2, 3-dichloroaniline by a three-step nucleophilicsubstitutionreaction in yield of 83%, 91% and 90%, respectively.
Five derivative dyes from the parent dyes were obtained by similar nucleophilicsubstitutionreaction in which five primary amines were employed as the nucleophilic reagent.