The low survival rate of the grafted neurons is one of the main obstructs in the clinically application of neural transplantation.

Conclusion MSCs can be induced to differentiate into neuron-like cells by human brain tissue extracts, which provide the bases for neural transplantation and repair.

Allogeneic or xenogeneic neural transplantation has yielded some results, but it is still used in the research phase of animal testing, which is difficult for clinical application.