SATB1 is a nuclear protein well known for its crucial role in regulating gene expression during the differentiation and activation of t cells, making it a key player in the immune system.

The study results suggested that the measurement of nuclear DNA of tumor cells may be helpful to ascertain the degree of differentiation and malignancy of nephroblastomas.

Hepatocyte nuclear factor 3 (HNF3) proteins play pivotal roles in the regulation of metabolism and the differentiation of the metabolic tissues such as pancreas and liver.