Chloride channel blockers, NPPB and ATP, inhibited the currents reversibly. Moreover, the inhibition of ATP on the outward currents was stronger than that on the inward currents.
氯通道阻断剂atp和NPPB可逆性地抑制此电流,ATP的抑制作用在外向电流显著强于内向电流。
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CONCLUSION: the chloride channel blockers NPPB or NFA lessen the oxidative injury of C6 cells through modulating the function of membrane and down-regulating the protein expression of CLIC4.