The manufacture process of nicotinic acid based on ammonia oxidation method, which is introduced in this article, reached 99% conversion of 3-methylpyridine.
A method was established for determining two intermediates in synthesis of imidacloprid, 2 chloro 5 methylpyridine and 2 chloro 5 chloromethyl pyridine by HPLC.
In the picoline pyrolysis experiment, the methyl disengages from aromatic ring to form methane firstly, then the following reaction of the aromatic ring is similar to pyridine.