Past structural studies of methylation were hindered by the extreme difficulty of constructing homogeneous samples of histones bearing methyl groups attached to specific lysine residues.
过去甲基化的结构研究被阻碍的原因是因为很难制备组蛋白特定部位赖氨酸甲基化的均一样品。
2
The repressive mark was composed of three methyl groups attached to a lysine on the H4 histone.
抑制性标记由3个甲基基团组成，结合到组蛋白H4的一个赖氨酸残基上。
3
However, Shokat and his colleagues had synthesized a chemical structure in the lab that mimics lysine with the methyl groups attached.