Chromatography is a mature science for isolation and analysis, which can be used in theoretical and technical studies.

To uses the Kuhnian terminology, is it a pre-paradigm or post-paradigm or, to use the Lakatosian’s, is it an immature or mature science?

So thermodynamics, based on these four laws now, requires an edifice, and it's a very mature science, and it requires that we define things carefully.