The cognitive function was assessed by mini mental state examination (MMSE) scale. All subjects were administered the physical examinations and biochemical testing of blood, including the hemoglobin.

Methods 193 normal subjects were tested by mini-mental state examination (MMSE), word immediate recall and word delayed recall test, clock drawing test, digit span test and verbal fluency test.

The mini-mental state examination (MMSE) and the computerize ANT software were performed in the patient and controls, to evaluate intelligence and record the reaction time (RT).