To study the potential application value of different metabolicactivation systems in human cell transformation models.
探讨不同的代谢活化系统在人细胞转化模型中潜在的应用价值。
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Therefore it is recommended to combine the yeast assay with the metabolicactivation method based on H4IIE cell line to assay the direct and indirect estrogenic chemicals in environmental samples.
Results It was proved that a CHL 3a4 transgenic cell line was established, which could lead metabolicactivation for aflatoxin B1 (AFB1), sterigmatocystin (STC) and cyclophosphamide (CPA).