The World Health Organization reports that depression has the greatest burden of disease worldwide, in terms of the total cost of treatment and the loss of productivity.
世界卫生组织报告称，从治疗总费用和生产力损失来看，抑郁症是世界上产生的负担最重的疾病。
2
The house was a totalloss and the insurance company promptly paid us the policy limit.
房屋被定为全损，保险公司按保险限额迅速赔付了我们。
《柯林斯英汉双解大词典》
3
We can exclude the possibility of totalloss from our calculations.