?可被几种蛋白激酶(Mitogen Activated Protein Kinase Kinase Kinases)
医学论文,生长激素诱导心肌细胞外信号调节酶激活及其上游调控 protein kinase kinase)磷酸化ERK的苏氨酸和酪氨酸残基使ERK活化。而MEK可被几种蛋白激酶(mitogen-activated protein kinase kinase kinases, MAPKKKs)磷酸化丝氨酸残基而激活，形成MAPKKK→MEK→ERK瀑布激活链。对一些细胞株的研究表明Raf-1