ObjectiveTo investigate the effect of NMDA receptor antagonist MK801 on the negative affection induced by withdrawal from acute morphine dependence in rats.
目的谷氨酸NMDA受体拮抗剂地卓西平（MK801）对大鼠急性吗啡依赖戒断性情绪反应的影响。
2
Nitric oxide, an intracellular messenger molecule linked to activation of N Methyl D aspartate(NMDA) receptor, plays a role in morphine tolerance and dependence.
OBJECTIVE:To elucidate the effect of ondansetron(OND), a 5-HT3 receptor antagonist, on the morphine-induced conditioned place preference(CPP) in mice and its possible mechanism.