Objective To investigate the changes in CREB-1 protein expression in three brain regions induced by acute or chronic morphinedependence and withdrawal.
ObjectiveTo investigate the effect of NMDA receptor antagonist MK801 on the negative affection induced by withdrawal from acute morphinedependence in rats.
目的谷氨酸NMDA受体拮抗剂地卓西平(MK801)对大鼠急性吗啡依赖戒断性情绪反应的影响。
3
Conclusion morphine may affect purine nucleotide metabolism of nerve cells, increase the adenylate and adenosine levels, which may be one of the mechanism of morphinedependence and tolerance.