The current recommended second-line treatment regimens are complex, of long duration, and require intensive monitoring of adverse events and treatment outcomes.

Learning the names of seasons, months, the days of the week and how to tell the time. Learning to say what time it is and giving duration (the current time and how long things take).

The diameter of the impeller is reduced through cutting impeller to improve the factual performance, reduce noise and motor current, so that it can be run steadily for a long duration.