OBJECTIVE to determine optimized prescription and technique for preparing brucine long-circulatingliposomes (BLCL) by means of optimization screening, and to evaluate its quality.
目的通过优化手段筛选最佳处方及工艺,制备马钱子碱长循环脂质体,并评价其质量。
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METHODS The longcirculating mitoxantrone liposomes were prepared by ammonium sulphate gradients method.
方法采用乙醇注入合并硫酸铵梯度法制备米托蒽醌长循环脂质体。
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CONCLUSION a simple and accurate method is established to determine the content of puerarin in puerarin longcirculatingliposomes and the entrapment efficiencies of liposomes.