The snag with most localanaesthetics is their lack of specificity.
大多数局部麻醉剂的问题是，它们的作用没有针对性。
2
Most localanaesthetics used clinically are relatively hydrophobic molecules that gain access to their blocking site on the sodium channel by diffusing into or through the cell membrane.
大多数应用于临床的局麻药物都是相对疏水性的分子，可弥散通过细胞膜，作用于阻滞部位的钠通道。
3
The enantiomer-specific structure of localanaesthetics has large impact on the pharmacokinetic process of these drugs, including absorption, protein-binding ratio, metabolism, and so on.