Taxol can inhibit mitosis of the microtubule network renewable, prevent mitoticspindle lead to the formation of chromosome break, inhibit the replication of tumor cells.
Sarcomas, including leiomyosarcomas, often have very large bizarre giant cells along with the spindle cells. A couple of mitotic figures appear at the left and lower left.
Accurate chromosome segregation depends on the precise regulation of mitotic progression, including the timing of mitosis and proper regulation of spindle assembly checkpoint.