Taxol can inhibit mitosis of the microtubule network renewable, prevent mitotic spindle lead to the formation of chromosome break, inhibit the replication of tumor cells.
The cell mitotic index decreased when the concentration of MH increased in a certain range, however, the ratios of micronucleus and chromosome aberration could increase.
随着盐酸吗啉胍处理浓度的增加，有丝分裂指数降低，而微核率和染色体畸变率均升高；
3
Accurate chromosome segregation depends on the precise regulation of mitotic progression, including the timing of mitosis and proper regulation of spindle assembly checkpoint.