Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers.
细胞周期蛋白D1作为一个能促进有丝分裂和CDK4的变构激活剂，是癌症中较频繁变化的细胞周期调节子。
2
Concomitantly, this compound showed mitogenic activity when challenged with normal lymphocytes and was also found to be involved in the inflammatory response.
与此同时，表明这种化合物有丝分裂活动时，与正常细胞的挑战，同时也发现，参与炎症反应。
3
Objective To discuss the relationship between estradiol and the mitogenic activated protein kinase signal transduction pathway and the expression of the MAPK in the MCF-7 breast cancer cell-line.