Infection with liver flukes has been reported to be associated with some liver and gall diseases, especially the cholangiocarcinoma.

GABA is known as an inhibitory transmitter of mammalian CNS, and produced excitation on liver flukes but, on the contrary, produced inhibition on chicken round-worms.

This paper reviews the epidemiological, clinical, experimental and pathological studies on the relationship between liver flukes infestation and diseases of liver and gall.