| 释义 |
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This paper reviewed the relationship between DNA mismatch repair, chromosome instability and cancer. 本文就DNA错配修复、染色体不稳定和肿瘤之间的联系予以综述。 - 2
If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis. 双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。 - 3
Several factors, such as defects in chromosome segregation and DNA damage response, failure of cell cycle checkpoint, telomere dysfunction, may cause chromosomal instability. 多种细胞机制功能障碍将导致染色体不稳定性，包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。
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