The key ofantibody-mediated immunological therapy is strong specificity of target antigen, low immunogenicity, high affinityofantibody and so on.
而抗体介导的免疫治疗的关键是靶抗原的特异性强,抗体的免疫原性低及亲和力高等。
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Conclusion With the increase of the immunization times, the affinityofantibody come to mature and the proportion of dominant linear epitopes of BSA became higher.
Because this method was to simulate the process ofantibody maturation in vivo, the obtained antibodies was not only fully humanized but also with relatively high affinity.