| 释义 |
1 [生化]?天然构象 蛋白质折叠问题 ? 天然构象 （ native conformation ）：具有 生物学功能的蛋白质的稳定的三维结构， 并在发挥功能过程中维持这种空间结构。
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Furthermore, calreticulin retains proteins in non-native conformation within the er and targets them for degradation (2, 3). 此外，在内质网中，钙网蛋白以非天然构象保存，并对其进行靶向降解(2,3)。 - 2
The reactions between aldolase and TNBS suggest that the amino group or groups, in snake aldolase, may play a special role in maintaining its native conformation. 醛缩酶和TNBS之间的反应支持酶分子的氨基，尤其是蛇肌醛缩酶的氨基在维护其天然构象中起着特殊作用的观点。 - 3
From the view of thermodynamics, native complex is the structure with the lowest binding free energy. Therefore, the aim of docking is to find the conformation with the lowest binding free energy. 通常热力学上认为生物分子的稳定构象是自由能最低的构象，因此，分子对接的目的就是找到能量最低的构象。
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