A method was established for determining two intermediates in synthesis of imidacloprid, 2chloro 5 methyl pyridine and 2chloro 5 chloromethyl pyridine by HPLC.
In this thesis, 2-chloro-5-chloromethyl pyridine is ammoniated, which followed by the reaction with N-cyano ethyl ethylimidoate, finally is methylated to gain the objective product.