The most common adverse events of etanercept included injection site reaction and upper respiratory infection in our study.

In the postmarketing period, additional cases of injection site reaction with features including induration, cellulitis, hematoma, abscess, sterile abscess, and necrosis, have been reported.

Methods the observation group patients used rotation card, the control group patients did not use the rotation card, compared the incidence of adverse reaction at injection site.