The two companies have moved linaclotide into late-stage testing in 2, 500 patients with IBS and chronic constipation.
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2.
Once linaclotide reaches the gut, it binds to a receptor on the lining of the intestine and activates a cellular messenger called cyclic guanosine monophosphate.
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3.
They created linaclotide out of 14 amino acids, 6 of which are cysteines that bind so tightly they keep the whole from getting dissolved by stomach acid or chewed up by digestive enzymes in the intestines.