When the weak acid is given orally, the concentration gradient for un-ionizeddrug between stomach and plasma tends to be large, favoring diffusion through the gastric mucosa.
当这种弱酸性药物经口服给药时,胃与血浆之间的非解离型药物浓度梯度很大,从而有利于透过胃粘膜扩散。
2
Thus, drug penetration may be attributed mostly to the un-ionized form.