Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis.
由于突变而引起的这些核心通路和调节过程的失调，是胰腺癌形成的主要特征性改变。
2
Somatic mutation, a main biological phenomenon of citrus and other fruits, is often used for breeding as a major variation source. Spontaneous mutations often occur in citrus.
体细胞突变是柑橘等果树比较常见的生物学现象，也是品种选育，即芽变选种的主要变异来源。
3
Conclusions No functional FANCA protein was found in these 3 cases of FA-A, and intragenic deletion, frame shift and splice site mutation were the major pathogenic mutations found in FANCA gene.