In our study, we found that methadone is also a potent inducer of cell death in leukemia cells and we clarified the unknown mechanism of methadone-induced cell killing in leukemia cells.
The ultrastructure of prematurely condensed chromosomes (PCC) in BK cells and the CHO metaphase chromosomes (the PCC inducer) were studied with cell fusion technique and SEM.
By derived differentiation, we mean that under the effect of differentiation inducer, malignant tumor cell has the tendency to differentiate to normal cell, even became normal cells.