Methods: the mice were immunize with LOVO, and the mAb were screened by indirect cell ELISA and immunohistochemistry.

The liver is the majority of medicines transformation metabolism place, when liver metabolism, some medicines itself and its metabolite may have direct or the indirect toxic damage to the liver cell.

The results of indirect immunofluorescence and cell binding suggest that IMMS can effectively bind target cells while do not have nonspecific binding activity.