Studies have shown that protease molecule with two non-active site binding groove (allostericsite), can be used to develop drug resistance against HIV, the new strategy.
但这是一个开始，佩里曼表示，这一研究结果为开发新型的抗艾滋病药物奠定了结构基础。
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When the product accumulates beyond an optimal amount it binds to a site (ALLOSTERICsite) on the enzyme, changing the shape so that it can no longer react with its substrate.