In 1990s, molecular biological approach has led to a series of cloning and functional expression of ligand-gated P2X receptors and G-protein coupled P2Y receptors.
This divalent cation is released from presynaptic vesicles into the synaptic cleft upon neuronal activity and acts as a modulator of many ligand-gated ion channels.
锌离子随着神经元的活动从突触前膜的囊泡中释放到突触间隙，对突触内受体进行调控。
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Because the binding of the neurotransmitter (ligand) to the receptor activates these ion channels, they are called ligand-gated channels to distinguish them from voltage-gated channels.