In cells with high PHGDH expression, the serine synthesis pathway contributes approximately 50% of the total anaplerotic flux of glutamine into the TCA cycle.
在PHGDH高表达的细胞中，丝氨酸合成途径为三羧酸循环贡献了接近总量50%的谷氨酰胺回补通量。
词源
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anaplerotic:
From anaplerosis, from Ancient Greek ?ν? ?(aná, “up”) + πληρ?ω ?(plēróō, “to fill”).