Biaryl substituted pyrazole compounds are sodiumchannelblockers useful for the treatment of pain and other conditions.
联芳基取代吡唑化合物为钠通道阻滞剂,用于治疗疼痛和其它病症。
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Here we show that charged sodium-channelblockers can be targeted into nociceptors by the application of TRPV1 agonists to produce a pain-specific local anaesthesia.
CONCLUSION Tetrandrine, as a calcium channelblockers, can reverse LVH induced by RH and elevate the cardiomyocytic membrane sodium pump and mitochondrial calcium pump activities.