The study shows that the inactivationofgene Atp6v0d2 in mice results in dramatically increased bone mass due to defective osteoclasts as well as enhanced bone formation.
DNA methylation may be an important mechanism ofinactivationof RUNX3 gene in HCC.
甲基化机制可能是肝细胞癌runx3基因失活的重要机制之一。
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The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing, X inactivation and genomic imprinting.