Mutations in the Leucine-rich repeat kinase 2 are the major cause of genetically-linked late onset Parkinson's affecting a high proportion of individuals with Parkinson's in certain populations.

Most of plant disease resistance (r) genes cloned so far belong to NBS LRR group which contains nucleotide binding sites (NBS) and a leucine rich repeat (LRR).

There is conservative domain in protein products of the many known genes, such as nucleotide binding site (NBS), leucine rich repeat(LRR) and transfer membrane(TM).