The immunological mechanisms which might be involved in transforming a local immune reaction into a systemic disorder are numerous and need further investigation.
在将局部免疫反应转变为系统性疾病的过程中，可能会涉及众多免疫机制，这需要进一步开展研究。
2
The pathogenesis of chronic hepatitis B is very complicated. There are not only the sustained existence of HBV, but also the immunological function disorder;