All of the 2,4 pyrrolindinediester derivatives were reduced with lithiumaluminumhydride in anhydrous THF, and ten new chiral 2,4 Dihydroxylmethylpyrrolidine derivatives were found.
然后，在无水THF中用氢化铝锂还原，得纯的手性2 ，4 二羟甲基四氢吡咯衍生物。
2
The synthesis of key intermediate of Gliclazide can be improved by using Potassium borohydride instead of Lithiumaluminumhydride. The procedure is suitable for industrial production.