This article reviews the effect of biotherapy in ra including tumor necrosis factor inhibitor, IL-1inhibitor, stem cell transplantation genetic therapy and so on.
Objective To investigate the circadian variation of serum interleukin 6 (IL 6) and cortisol and their clinical value in rheumatoid arthritis (RA) patients.
目的研究类风湿关节炎（RA）患者血清白细胞介素（IL） 6、皮质醇节律及其临床意义。
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In recent years studies, it has been shown that IL-18 participated in the genesis of RA, which has become a new hot spot of RA study.