The HR protein has long been suspected to regulate a stem cell-mediated process, hair cycling, as mutations in the Hrgene cause hair loss in both mice and men.
HR蛋白被怀疑调节干细胞介导的毛发周期，如HR基因导致毛发脱落，无论在人还是在鼠。
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The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression.