However, their therapeutic use is often hindered by problems such us poor water solubility, acquireddrug-resistance and strong toxicity.
但由于水溶性差、易产生多药耐药性和毒性较强等缺点限制了它们在临床上的应用。
2
Alternatively, acquireddrugresistance results when tumors initially respond to therapy but become refractory to subsequent treatments.
或者，当肿瘤最初响应于治疗但对随后的治疗变得难以治愈时，就会导致获得性耐药性。
3
The varieties of antibiotics are used widely and the bacterial drugresistance appears greatly. P. aeruginosa have acquired a great resistance and multiple resistance by many methods.