MGMT and TP53 genes play an important role in maintaining genomicstability and protecting cells against mutations or carcinogenesis.
MGMT和TP53基因在保持基因组稳定性和防止细胞突变或癌变方面具有重要的功能。
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Using yeast as model organism, study the contribution of epigenetic regulation to the maintenance of genomicstability, by epigenetic, molecular genetic and biochemic approaches.
In these tumours with an altered control of genomicstability, accumulation of chemotherapy-induced genetic alterations may contribute to cell death and account for complete response.