P-TEFb is a generaltranscriptionfactor that regulates transcription elongation through phosphorylation of the C-terminal tail domain (CTD) of RNA polymerase II (RNAP II).
P - TEFb是一个普通的转录因子,它通过磷酸化rna聚合酶ii (RNAP II) C -末端尾巴结构域(CTD)来调节转录延伸。
2
Surprisingly, the factor turns out to have been previously characterized as a general repressor of transcription, NC2, an observation explained by its ability to repress TATA-box-containing promoters.