医药科学

• 分泌过多

  The presence of increased oxidative stress is a critical feature in the pathogenesis of COPD, since it results in inactivation of antiproteinases, airspace epithelial injury, mucus hypersecretion, increased sequestration of neutrophils in the pulmonary microvasculature, and gene expression of pro-inflammatory mediators.

  由于氧化／抗氧化失衡可导致抗蛋白酶失活、气道上皮损伤、粘液分泌过多、增加中性粒细胞在肺微脉管系统的聚集及前炎症介质的基因表达，故氧化／抗氧化失衡的存在是COPD的发病机制的重要特征之一。