Once in the bloodstream, sugar bonds with protein and creates advanced glycation end products (aptly abbreviated AGEs), which cause collagen to become inflamed and stiff, leading to wrinkles.

Objective To investigate the effects of advanced glycation end products (AGE) on secretion of monocyte chemoattractant protein-1(MCP-1) by human endothelial cells and its signal transduction pathway.

Objective: To study the effects and the mechanism of advanced glycation end products on bovine vascular smooth muscle cell in vitro.