Alveolar air space fraction was greater in Disease rabbits, suggestive of emphysema improved by expansion thoracoplasty.

Alveolar oxygen into nitrogen compounds, lead to the formation of nitrite and nitrate, a sharp stimulus to the lung tissue, increased pulmonary capillary permeability, leading to emphysema.

In emphysema, the alveolar walls are enlarged, and large air Spaces have formed where the alveoli should be.