Objective To study the relationship between hepatic insulin resistance induced by high fat diet and the expression of genes involving hepaticglucoseoutput.
目的观察高脂饮食饲养造成的肝脏胰岛素抵抗与肝糖输出有关的调控基因表达的关系。
2
Loss of first-phase response has metabolic consequences: lack of rapid insulinization of the liver delays the suppression of hepaticglucoseoutput and causes therefore postprandial hyperglycemia.
第一相胰岛素反应丧失的后果为肝脏未能迅速胰岛素化,延迟了对肝葡萄糖输出的抑制,从而引起餐后高血糖。
3
Infact, insulin resistance in liver contributes to the excessive hepaticoutput of glucose, which is highly correlated with hyperglycemia in type 2 diabetes.