But at present, many anti idiotypic antibodies are mouse original antibodies, which can cause humanantimouseantibody (HAMA) response and decrease the curative effect.
但由于目前所使用的抗独特型抗体多为鼠源性，用于人体可产生人抗鼠抗体反应，从而影响疗效。
2
In order to reduce the humanantimouseantibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.
为了降低人抗鼠抗体反应，获得满意的免疫原性，将模拟人卵巢癌抗原的抗独特型单链抗体人源化。
3
Dotted or small focal expressions were found in SCID mouse liver when detecting the human serum albumin with mouseanti-human albumin antibody after transplantation of the stem cells in 3 months.