医药科学

• 呋喃

  Furane or thiophene ring substituted for benzene ring of benzylidene, activity of the compounds would be increased. Furthermore, the compounds containing hyper-conjugate skeleton were more potent.

  取代苯亚甲基的苯环的对、间位取代给电子基团时，活性较好，邻位取代的活性降低；苯环取代吸电子基团时活性相对较差，而无取代时几乎无活性；芳香环为呋喃、噻吩的活性高于苯环；共轭程度高的化合物，活性较好。