Global hypomethylation and regional hypermethylation are common mechanisms of aberrant expression of gene.
广泛的低甲基化和区域性高甲基化是基因异常表达的常见机制。
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DNA hypomethylation often displays considerable specificity with regard to tumor type, tumor stage, and sequences affected.
DNA甲基化且与肿瘤类型、肿瘤分期及肿瘤侵袭的顺序中表现出相当的特异性。
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But the mechanism isn't perfect: "If you look at tumors, they tend to have hypomethylation overall, but hypermethylation in some genes," Sapienza says.